… Application of GIRs 1 and 6 (Subheading Note 1 (a) to Chapter 30). Adoption : 1995 … 2. Peginterferon alfa-2a … C. Application of GIRs 1 and 6 (Subheading Note 1 (a) to Chapter 30). Adoption : 2009 … 3. Peginterferon alfa-2b … methionine residue of the filgrastim polypeptide chain by a reaction called reductive amination. …